Cancer and DMBA-DNA adduct formation?

DMBA is 7,12-Dimethylbenz(a)anthracene is a powerful organ-specific laboratory carcinogen.[2] Also known as 7,12-dimethylbenz[α]anthracene or DMBA, this substance is widely used in many research laboratories studying cancer.

DMBA serves as a tumor initiator by making necessary mutations. Tumor promotion can be induced with treatments of 12-O-tetradecanoylphorbol-13-acetate (TPA) in some models of two-stage carcinogenesis.[3] This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.

FYI, DMBA is a cancer/tumour inducer. DMBA-DNA adducts are the result of the binding of DMBA metabolites to DNA, and these markers are what researchers use as a measure of incidence of cancer.

1st POINT:
What they discovered was that there was a polysaccharide compound (6-D-glucopyranose pentaacetate) found in the Noni that INCREASED THE ABILITY OF THE IMMUNE SYSTEM TO PRODUCE CHEMICALS THAT ENHANCED THE KILLING POWER OF THE WHITE BLOOD CELLS.


2nd POINT:
Xeronine is an alkaloid which is important for proper cell function. It is usually supplied to the body as the precursor "pro-xeronine", which is converted to xeronine in the intestines. It is believed to regulate the rigidity and shape (hence the function) of specific proteins, affecting a wide range of physiological reactions, including repair to damaged cells; enhanced host immune system involving macrophages and/or lymphocytes(1); and analgesic affects(2).
Proxeronine travels into the cytoplasm of the body’s cells and accumulates in their Golgi Apparatus (GA). Within the GA, Proxeronine combines with different body biochemicals such as hormones, enzymes, serotonin, antioxidants, vitamins, minerals, and other elements. The combination of Proxeronine and the other biochemicals are in specific and varied combinations depending on how the body’s homeostasis is out of alignment.
The GA acts as an “assembler” combining just the right amounts of Proxeronine with the tight proportions of the different biochemicals. The GA then packages it, addresses it, and mails it to the particular “sick” cell addresses. The blood acts as the highway from the GA to the “sick cells”. Once the specific package arrives, it is opened and all of the inside constituents are released in close proximity to the “sick” cell. Then proxeronine, under the influence of Proxeronase, ( a substance found naturally in the body) is converted to xeronine (an alkaloid), Xeronine combines with the correct mixtures of biochemicals to create the specific adaptogen for that particular “sick” cell.


3rd POINT:
Japanese scientists found was that one of the phytochemicals in the Noni extract does exactly that! They found that it was the phytochemical in the Noni extract which goes by the fancy name of Damnacanthal that does this. When they added the Noni extract to RAS activated cancer cells they observed them daily for five days. What they saw was incredible!

They reported that slowly, day by day the cells began to change their morphology (cell structure) back to normal. It is only on the basis of this kind of hard science that doctors can rely upon the ability of a plant extract to produce the return to good health now being seen clinically by people who have been struggling with cancer. No one knows if Noni will produce a return to good health for any specific person, but the research shows there is a scientific basis for believing that it is possible.

No commercial company makes any medical claims and is not associated with the contents of this document in any way. This document is a compilation of information gathered from the listed and other sources and is provided here for your education only. It is in no way meant to be taken as medical advice or be used as a substitution for any medical treatment. Consult your physician with any questions.

Source : Nonimaui.Com