Morinda citrifolia (Noni) has been extensively used in folk medicine by Polynesians for over 2,000 years. It has been reported to have broad therapeutic effects, including anticancer activity, in both clinical practice and laboratory animal models. The mechanism for these effects remains unknown.
The hypothesis that Morinda citrifolia possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied. Our preliminary data indicated that 10% Tahitian Noni Liquid Dietary Supplement or Tahitian Noni Juice (TNJ), made from Morinda citrifolia fruit by Morinda Inc, in drinking water for one week was able to prevent DMBA-DNA adduct formation. The levels of DMBA-DNA adducts were reduced by 30% in the heart, 41% in the lung, 42% in the liver, and 80% in the kidney of female SD rats.
Even more dramatic results were obtained in male C57 BL-6 mice: 10% TNJ was able to reduce DMBA-DNA adduct formation by 60% in the heart, 50% in the lung, 70% in the liver, and 90% in the kidney. In order to explore the mechanism of this preventive effect, the antioxidant activity of TNJ was examined in vitro by lipid hydroperoxide (LPO) and tetrazolium nitroblue (TNB) assays. In the LPO assay, LPO oxidizes leucomethylene blue to methylene blue in the presence of hemoglobin.
The resultant blue color was quantified at 660 nm spectrophotometrically. In the TNB assay, superoxide anion radicals (SAR) reduce TNB into formazan blue that was also measured by absorption at 602 nm. TNJ showed a dose-dependent inhibition of both LPO and SAR in our system. The antioxidant activity of TNJ was compared to the effects of vitamin C, grape seed powder (GSP), and pycnogenol (PYC) at the daily dose per serving level recommended by U.S.RDAs or manufacturers.
The results suggest that prevention of carcinogen-DNA adduct formation and the antioxidant activity of TNJ may contribute to the cancer preventive effect of Morinda citrifolia.
Source : Department of Pathology, UIC College of Medicine, Rockford, Illinois 61107, USA. mianwang(a)uic.edu
Thursday, January 29, 2009
TESTIMONIAL : Noni Treat Breast Cancer
My name is Diana Morrell. I am 56 years old. On December 23rd 1994 I heard the words that every woman fears. "From all the indications it appears you have breast cancer. As soon as Christmas is over we will have to do a biopsy to be sure."
I don’t need to tell you that Christmas was not a happy time that year. On Dec. 27th I had the biopsy and it came back positive. Fortunately I had a wonderful young doctor who advised me to have a lumpectomy and chemotherapy. Thus saving me the further trauma of loosing my breast. On January 7th I learned that the cancer was in my lymph nodes. I went ahead and endured chemotherapy. Yes all my hair fell out and it was a very difficult time.
During this time I took lots of vitamins minerals and even used the mushroom tea that was so popular at that time. Another problem that I had was depression. Many factors caused this and I was finally given Zoloft to help me snap out of my poor state of mind. I know you are asking, "Why didn’t she just take Noni juice?" If you will look at the dates you will see that Noni was not available to the general public at that time.
It wasn’t until November 1996 that a good friend of mine, Jacqueline Miller, called and told me about Noni. Always one to try anything I feel will help my health I immediately bought a bottle. Within a few weeks I noticed I was feeling better but it took a couple of months for me to realize that it was the Noni that was making the difference. My doctors are amazed at how well I have done the last few years and how well my blood count has gone back to normal. I also was able to get off the Zoloft two years ago and have never felt the need to go back on. I’m now sure that I could have gotten off sooner but things were going so well that I was afraid to change anything.
I am now in my last six months before I get to that infamous five-year mark. I am doing great and all my blood work indicates that everything is normal. I would be lying if I told you that I don’t worry about the cancer coming back but everyday cancer free is another step away from that fear. I plan to take Noni for the rest of my life.
By Diana Morrell
I don’t need to tell you that Christmas was not a happy time that year. On Dec. 27th I had the biopsy and it came back positive. Fortunately I had a wonderful young doctor who advised me to have a lumpectomy and chemotherapy. Thus saving me the further trauma of loosing my breast. On January 7th I learned that the cancer was in my lymph nodes. I went ahead and endured chemotherapy. Yes all my hair fell out and it was a very difficult time.
During this time I took lots of vitamins minerals and even used the mushroom tea that was so popular at that time. Another problem that I had was depression. Many factors caused this and I was finally given Zoloft to help me snap out of my poor state of mind. I know you are asking, "Why didn’t she just take Noni juice?" If you will look at the dates you will see that Noni was not available to the general public at that time.
It wasn’t until November 1996 that a good friend of mine, Jacqueline Miller, called and told me about Noni. Always one to try anything I feel will help my health I immediately bought a bottle. Within a few weeks I noticed I was feeling better but it took a couple of months for me to realize that it was the Noni that was making the difference. My doctors are amazed at how well I have done the last few years and how well my blood count has gone back to normal. I also was able to get off the Zoloft two years ago and have never felt the need to go back on. I’m now sure that I could have gotten off sooner but things were going so well that I was afraid to change anything.
I am now in my last six months before I get to that infamous five-year mark. I am doing great and all my blood work indicates that everything is normal. I would be lying if I told you that I don’t worry about the cancer coming back but everyday cancer free is another step away from that fear. I plan to take Noni for the rest of my life.
By Diana Morrell
NONI RESEARCH : Lab Test on Mice show Noni Helps The Body Fight Off Cancer!
Anti Cancer Activity of Morinda Citrifolia on Intraperitoneally Implanted Lewis Lung Carcinoma in Syngenic Mice A. Hirazumi, E. Furusawa, S.C. Chou & Y. Hokama Proc. West. Pharmacol. Soc. 37: 145-146 (1994)
This is a significant study by a team of researchers from the University of Hawaii led by Annie Hirazumi. Ms. Hirazumi became interested in the healing properties of Noni after two prior experiences. Her father once gave Noni juice to a sick friend; and later, she administered Noni juice to a pet dog who was dying. The dog miraculously recovered, and Ms Hirazumi became determined to learn more about this incredible fruit.
The study was conducted on live laboratory mice (type C57BL/6) specifically identified as being acutely receptive to Lewis Lung Carcinoma (LLC) cells. The mice were injected with active cancer cells (LLC). Untreated, the mice died 9-12 days after injection due to advanced tumor growth. A second group of infected mice was treated with Noni juice in five separate daily treatments.
This group demonstrated a significantly increased life span, from 105--123%, with 9 of 22 mice surviving more than 50 days. For verification purposes, the experiment was repeated with similar results. The research team concluded that Noni juice acts as an anti-cancer agent by indirectly enhancing the cancer host's immune system of macrophages and/or lymphocytes.
DETAILS:
1. Researchers at the University of Hawaii School of Medicine introduced cells containing a strain of lung cancer known as Lewis Lung Carcinoma into a group of mice especially bred to be highly susceptible to this type of cancer.
2. Within 9 to 12 days the mice which were given no Noni were all dead as a result of the growth of the tumor. However, another group of these same mice were given an extract of the Noni fruit on five different occasions.
3. At the end of the 12 days when all the untreated mice were dead, those given the Noni were still alive and doing well! At the end of 24 days, the Noni treated mice were all still going strong, this was a 100% extension of life! Actually, 40% which is 9 out of the 22 mice given the Noni, survived for more than 50 days.
4. This is a lifespan more than 4 times greater than the longest living mouse not receiving the Noni. This an incredible achievement! Now remember, these were not just any mice, these mice were specifically bred to succumb to this form of cancer.
5. In this regard, they were "genetically doomed" to be cancer victims. Yet in spite of this, a simple Noni extract gave these mice as much as 4 times the life span of their untreated relatives.
Source : http://www.nonialoha.com/noni_research.htm
This is a significant study by a team of researchers from the University of Hawaii led by Annie Hirazumi. Ms. Hirazumi became interested in the healing properties of Noni after two prior experiences. Her father once gave Noni juice to a sick friend; and later, she administered Noni juice to a pet dog who was dying. The dog miraculously recovered, and Ms Hirazumi became determined to learn more about this incredible fruit.
The study was conducted on live laboratory mice (type C57BL/6) specifically identified as being acutely receptive to Lewis Lung Carcinoma (LLC) cells. The mice were injected with active cancer cells (LLC). Untreated, the mice died 9-12 days after injection due to advanced tumor growth. A second group of infected mice was treated with Noni juice in five separate daily treatments.
This group demonstrated a significantly increased life span, from 105--123%, with 9 of 22 mice surviving more than 50 days. For verification purposes, the experiment was repeated with similar results. The research team concluded that Noni juice acts as an anti-cancer agent by indirectly enhancing the cancer host's immune system of macrophages and/or lymphocytes.
DETAILS:
1. Researchers at the University of Hawaii School of Medicine introduced cells containing a strain of lung cancer known as Lewis Lung Carcinoma into a group of mice especially bred to be highly susceptible to this type of cancer.
2. Within 9 to 12 days the mice which were given no Noni were all dead as a result of the growth of the tumor. However, another group of these same mice were given an extract of the Noni fruit on five different occasions.
3. At the end of the 12 days when all the untreated mice were dead, those given the Noni were still alive and doing well! At the end of 24 days, the Noni treated mice were all still going strong, this was a 100% extension of life! Actually, 40% which is 9 out of the 22 mice given the Noni, survived for more than 50 days.
4. This is a lifespan more than 4 times greater than the longest living mouse not receiving the Noni. This an incredible achievement! Now remember, these were not just any mice, these mice were specifically bred to succumb to this form of cancer.
5. In this regard, they were "genetically doomed" to be cancer victims. Yet in spite of this, a simple Noni extract gave these mice as much as 4 times the life span of their untreated relatives.
Source : http://www.nonialoha.com/noni_research.htm
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